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American Society of Microbiology ABMM Sample Questions:
1. A traveler returning from sub-Saharan Africa presents with cyclical fevers, chills, and sweats. A Giemsa- stained peripheral blood smear reveals multiple ring forms within red blood cells, some applique forms, and occasional banana-shaped gametocytes. No Schüffner's dots or red blood cell enlargement is observed. Which Plasmodium species is the most likely cause?
A) Plasmodium ovale
B) Plasmodium vivax
C) Plasmodium malariae
D) Plasmodium falciparum
2. Staphylococcus epidermidis, a common cause of healthcare-associated infections, forms biofilms on medical devices. The production of polysaccharide intercellular adhesin (PIA) is a key factor in biofilm maturation.
The expression of PIA is primarily regulated by:
A) The icaADBC operon, whose expression is influenced by environmental cues.
B) Horizontal gene transfer of the ica operon.
C) The stringent response pathway activated during nutrient limitation.
D) A two-component regulatory system involving AgrA and AgrC.
3. A clinical microbiology laboratory is preparing to validate a new molecular assay for the detection of methicillin-resistant Staphylococcus aureus (MRSA). To assess the positive predictive value (PPV) of the assay, they need to know:
A) The number of true negative results divided by the total number of negative test results.
B) The number of true negative results divided by the total number of true negative and false positive results.
C) The number of true positive results divided by the total number of true positive and false negative results.
D) The number of true positive results divided by the total number of positive test results.
4. A clinical microbiology laboratory is performing antimicrobial susceptibility testing on a Klebsiella pneumoniae isolate. The isolate is resistant to multiple beta-lactam antibiotics, and further testing reveals the presence of a carbapenemase enzyme. The MOST clinically significant carbapenemase in Klebsiella pneumoniae is often:
A) Klebsiella pneumoniae carbapenemase (KPC)
B) Extended-spectrum beta-lactamase (ESBL)
C) AmpC beta-lactamase
D) Metallo-beta-lactamase (MBL)
5. Histopathological examination of lung tissue from an immunocompromised patient reveals large (8-15 µm), spherical yeast cells with thick, refractile walls and characteristic single, broad-based budding. These findings are most suggestive of infection with:
A) Paracoccidioides brasiliensis
B) Blastomyces dermatitidis
C) Coccidioides immitis/posadasii
D) Histoplasma capsulatum
Solutions:
| Question # 1 Answer: D | Question # 2 Answer: A | Question # 3 Answer: D | Question # 4 Answer: A | Question # 5 Answer: B |


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